J.Jpn. Surg. Soc.. 123(1): 18-24, 2022

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Feature topic

DEVELOPMENT OF A NOVEL TECHNOLOGY TO PROMOTE THE FUSION OF PANCREATIC ISLET TRANSPLANTATION AND REGENERATIVE MEDICINE

Transplant medicine and regenerative medicine are closely related, and it is expected that regenerative medicine will effectively solve various problems associated with current transplant medicine. In this context, the findings obtained from cell transplantation therapy are extremely useful, and cell transplantation is considered a significant bridge between transplantation and regenerative medicine. Islet transplantation, a typical example of such cell transplantation therapy, is an ideal minimally invasive treatment for patients with severe type 1 diabetes who experience poor glycemic control. However, it is crucial for islet transplantation to be combined with regenerative medicine like other types of cell transplantation to extend this attractive treatment to more patients with severe diabetes in the future. In order to achieve an effective fusion of islet transplantation and regenerative medicine, it will be important to create radical innovations in each of the following three fields: improvement of subcutaneous islet transplantation methods; development of immunoisolated cell devices; and development of immunosuppressive agents suitable for islet transplantation and regenerative medicine as a more practical approach.

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