J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text HTML] [Full Text PDF] （in Japanese / 1914KB） [Members Only]

J.Jpn. Surg. Soc.. 119(4): 395-400, 2018

Feature topic

RECONSTRUCTING THE 3D KIDNEY

1) Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
2) Department of Urology, Kyushu University Graduate School of Medical Science, Fukuoka, Japan

Hidekazu Naganuma1)2), Ryuichi Nishinakamura1)

While many researchers are involved in the study of regenerative medicine, it is considered to difficult to regenerate the kidney because of its complex 3D structure. Three main types of progenitor cells constitute the kidney: nephron progenitors; ureteric buds; and stromal progenitors. By determining the developmental processes of these cells in vivo, we succeeded in inducing nephron progenitors and ureteric buds in vitro from mouse embryonic stem (ES) cells and human induced pluripotent stem cells. Moreover, we recapitulated the higher-order structure of the embryonic kidney from mouse ES cells. This article reviews the current status of research on kidney regeneration and discusses the issues to be resolved before clinical applications.

<< To previous pageTo next page >>

To read the PDF file you will need Adobe Reader installed on your computer.