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[Members Only] J.Jpn. Surg. Soc.. 119(4): 373-380, 2018
Feature topic
SMART 3D ORGAN CONSTRUCTION AND BLOOD VESSEL APPLICATIONS IN TISSUE ENGINEERING
Tissue engineering has contributed to significant breakthroughs in cardiovascular medicine, and tissue-engineered vascular grafts (TEVGs) hold immense potential to address complications related to current blood vessel replacements. The ideal TEVG construction is capable of remodeling, growing, and integrating into a host’s tissue. Past research has examined various material and engineering approaches, such as natural scaffolds containing extracellular matrix proteins or synthetic biodegradable polymers that have been cultured with and without bioreactors. As many previous approaches required extensive fabrication periods, current research is focusing on creating readily available, off-the-shelf, cost-effective TEVGs. While many obstacles exist in creating a TEVG that is capable of handling the diversity found clinically, the potential benefits of such an achievement are exciting. In this chapter, we review the history, biomaterial approaches, and current state-of-the-art technologies in cardiovascular tissue engineering.
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