J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text HTML] [Full Text PDF] （in Japanese / 209KB） [Members Only]

J.Jpn. Surg. Soc.. 116(6): 370-373, 2015

Feature topic

SIGNIFICANCE OF NONCODING RNA IN BREAST CANCER

Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

Fumiaki Sato

Noncoding RNA (ncRNA) has a crucial role in the molecular mechanisms of malignant features of breast cancer. This review outlines the biological and clinical significance of well-investigated microRNAs including let-7, miR-21, miR-200, miR-15/16, miR-155, and miR-221/222, and long ncRNAs such as H19, LSINCT5, HOTAIR, and GAS5. The biological roles of microRNAs secreted in the exosome are also described. Combined analysis of mRNA and ncRNA will help to develop the field of genetic diagnosis of breast cancer.

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