J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1883KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 103(2): 224-228, 2002

Feature topic

DRUG DELIVERY SYSTEMS FOR CANCER CHEMOTHERAPY

New Product Research Laboratories III, Daiichi Pharmaceutical Co.,Ltd., Tokyo, Japan

Kazuhiro Inoue

Various types of drug delivery system(DDS) for antitumor drugs have been developed to reduce severe systemic toxicities and to enhance antitumor effects by improving their pharmacokinetics. ln this paper, outlines are first given of the concept and design of DDS, focusing on polymeric antitumor drugs (macromolecular prodrugs) and then describing the superior DDS effects shown in preclinical studies of DE-310, a DDS optimized for the camptothecin analogue DX-8951. Clinical trials of DE-310 are now ongoing in the USA and Europe.

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