J.Jpn. Surg. Soc.. 95(7): 435-441, 1994

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Original article

RELATIONSHIP BETWEEN VENOUS INVASION AND HEMATOGENOUS METASTASIS IN THE GASTRIC CANCER

We investigated the correlation between venous invasion and hematogenous metastasis in gastric cancer. In 70 patients with gastric cancer, 8 cases had hepatic metastasis at operation (group A), 26 cases were identified with hematogenous recurrence after operation (group B) and 36 cases were disease free over 5 years after operation (group C). Specimens were all step-sectioned and serial sections were stained both with HE and EM. Rates of venous invasion were calculated as following formulae; (number of cancer involing veins/total number of veins investigated) ×100 (%). Results were as follows. 1. Average rates of venous invasion (ARVI) of groups A and B were significantly higher than that of group C (A; 7.6%, B; 2.6%, C; 0.7% p＜0.05). 2. In subserosal or serosal layer, there is no significant difference between ARVI of group A and that of group B. 3. No significant difference was seen between group A and B in rates of venous invasion to larger vein (diameter＞200 μm). These observations suggest that cancer invasion to the veins located in deeper than subserosal layer or ranged in diameter over 200 μm relates to hematogenous metastasis.

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