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J.Jpn. Surg. Soc.. 94(9): 966-976, 1993
Original article
OXYGEN CARRYING CAPACITY OF TOTALLY APTIFICIAL RED CELL SUBSTITUTE
－LIPOSOME EMBEDDED HEME－
IN HEMORRHAGIC BEAGLE DOGS
Liposome embedded heme (L/H) was produced by embedding synthesized lipid-heme in liposomes. The oxygen carrying capacity of this totally artificial oxygen carrier was evaluated in dogs. Under controlled ventilation, 30ml/kg of blood was drawn. Thirty minutes after bleeding, 30mg/kg of the L/H solution was intravenously injected in group I ( n=6) and the same volume of normal saline solution was injected in group II (n=7). No transfusion was performed in group III (n=7). In group I, mixed venous O
2 tension (PvO
2), O
2 transport (TO
2) and O
2 consumption (VO
2) increased significantly compared with those observed before injection of the L/H (p＜0.05). PvO
2 kept higher level compared with group II until 90 minutes after injection of the L/H (p＜0.05). Following the L/H injection, TO
2 by the dogs' Hb was 187ml/min and that by the L/H was 43ml/min. VO
2 from the dogs' Hb was 51ml/min and that from the L/H was 16ml/min. Thus TO
2 by the L/H provided 19% of the total TO
2 and VO
2 from the L/H provided 24% of the total VO
2. Thus, this exchange transfusion experiment show that the L/H has ability as an oxygen carrier to bind and to transport oxygen to the tissues.
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