J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2381KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 91(10): 1608-1616, 1990

Original article

THE PROGNOSTIC SIGNIFICANCE OF NUCLEAR DNA CONTENT IN NON-SMALL-CELL LUNG CARCINOMA

*) Department of Thoracic and Vascular Surgery, Oita Prefectural Hospital, Oita, Japan
**) Department of Pathology, Oita Prefectural Hospital, Oita, Japan

Norio Yamaoka*), Yoshitaka Uchiyama*), Kouji Kimino*), Shinji Akamine*), Satoshi Matsuo*), Koichi Tsuji**)

The nuclear DNA content of paraffin-embedded specimens of primary non-small-cell lung carcinomas was analysed using flow cytometry in 210 patients (80 squamous cell carcinomas, 99 adenocarcinomas, 19 large cell carcinomas and 15 others). The relationship between nuclear DNA content and prognostic factors was studied using multivariate analysis with Cox's proportional hazard model.
1) The frequency of DNA aneuploidy was 77.3% among 210 patients, and it signiflcantly (p＜0.05) increased with advanced stage and the presence of lymph node metastasis.
2) The patients with DNA aneuploid tumors had a signiflcantly (p＜0.001) less favorable prognosis than those with DNA diploid tumors among 179 patients with non-small-cell lung carcinomas. Similar results were demonstrated in 79 patients with stage I carcinomas and in 85 patients who underwent absolute curative resection.
3) Multivariate analysis using Cox's proportional hazard model showed that DNA ploidy was an independent prognostic factor for survival. Especially in the patients with absolute curative resection, DNA ploidy was the most important prognostic factor.
In conclusion, flow cytometric nuclear DNA content analysis provided useful biological information, and DNA ploidy was an important and major independent prognostic factor in non-small-cell lung carcinoma.

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