J.Jpn. Surg. Soc.. 91(10): 1591-1595, 1990
Original article
FLOW CYTOMETRIC ANALYSIS IN COLORECTAL CANCER WITH HEPATIC METASTASES AND ITS RELATIONSHIP TO METASTATIC CHARACTERISTICS AND PROGNOSIS
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Department of Surgery II, School of Medicine, Kanazawa University Akio Yamaguchi, Tetsuya Ishida, Genichi Nishimura, Masahiro Kanno, Takeo Kosaka, Yutaka Yonemura, Itsuo Miyazaki |
Primary carcinomas were DNA diploid pattern in 48.1%, DNA aneuploid in 51.9%. Of 31 hepatic metastases, 11 (35.5%) metastases showed a DNA diploid pattern, and 25 (64.5%) showed a DNA aneuploid pattern. Ploidy pattern was constant between primary and metastases in 80% of tumors. No significant relationship between metastatic characteristics and DNA ploid pattern was found. The DNA aneuploid cancers had a relatively poorer prognosis in patients with unresectable hepatic metastasis. In resected hepatic metastases from colorectal cancer, rate of hepatic recurrence with DNA diploid pattern was lower than that with DNA aneuploid pattern. Survival of patients with DNA diploid metastases (71% alive at 5 years) was significantly better than that of patients with DNA aneuploid metastases (21% alive at 5 years) (p＜0.05).
These results demonstrated that flow cytometric DNA ploidy measurements may have prognostic value for patients with hepatic metastases from colorectal cancer.
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