J.Jpn. Surg. Soc.. 89(3): 376-380, 1988

---

Original article

CHANGES OF PLASMA AMINO ACID PROFILES FOLLOWING TOTAL HEPATECTOMY UNDER VENO-VENO BYPASS IN DOGS

Patients with advanced liver disease demonstrate characteristic plasma amin acid abnormalities. The response of plasma amino acid patterns after liver transplantation in those patients is unknown. Mongrel dogs were subjected to two experimental models, that is, one is total hepatectomy under veno-veno bypass as an assumption of anhepatic phase in liver transplantation and the another is splenectomy as control. In control group, BCAA/AAA ratio rose gradually during operation. The levels of methionine, glycine and alanine were significantly lower at 4 hours. In hepatectomized dogs, BCAA/AAA ratio fell gradually after total hepatectomy. The levels of amino acids excent for BCAA were higher than preoperative value. Increase of alanine was the most remarkable early after total hepatectomy. It was derived not only from the lack of glucose-alanine cycle but also from increased synthesis due to degradation of the BCAA in muscle.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.