J.Jpn. Surg. Soc.. 88(6): 735-742, 1987
Original article
CLINICOHISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES ON INTRANCREATIC SPREAD OF PANCREATIC CARCINOMA
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The Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan Akimasa Nakao, Toru Ichihara, Toshiaki Nonami, Akio Harada, Hiroshi Takagi, Takashi Koshikawa*), Hiroshi Nagura*) |
In the observation of HE stained tissue sections of 25 cases of carcinoma of head of the pancreas, the intrapancreatic spread from the head to body or tail was observed in 9 out of 25 cases (36％). However, by the immunostaining of CEA, CA19-9 and Dupan 2, small cancer nests surrounded by fibrous tissues could be easily detected and intrapancreatic continuous spread from the head to body or tail was observed in 15 out of 25 cases (60％).
The intrapancreatic spread of the carcinoma correlated with portal invasion of carcinoma, hardness of the body and tail, obstruction of main pancreatic duct and irregular pancreaticogram.
The intraoperative quick immunostaining on the cryostat sections of the pancreatic tissue, together with the HE staining, is useful to determine the intrapancreatic spread of the carcinoma.
The indication of total pancreatectomy for pancreatic carcinoma can be determined by these results.
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