J.Jpn. Surg. Soc.. 88(6): 727-734, 1987

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Original article

EXPERIMENTAL STUDY ON MECHANISM OF ONSET OF ACUTE ULCER VIEWED FROM BLOOD COAGULATION AND ACTIVITIES OF FIBRINOLYSIS AFTER HEPATECTOMY IN LIVER CIRRHOSIS

Using liver cirrhosis rats induced by intraperitoneal administtration of 4％ thioacetamide (TAA) consecutively for 10 weeks, the authors made a study on the activities of blood coagulation and fibrinolysis in the onset of acute ulcer after hepatectomy. The results were as follows :
1. On the 3rd day after hepatectomy increase in the portal blood pressure, approximate 30％ decrease in gastric wall blood flow and increase in fibrinolysis in blood and gastric mucosa were observed. While no bleeding was recognized, edema and hyperemia were noticeable.
2. On the 3rd postoperative day when the maximum increase of fibrinolysis in blood and gastric mucosa was observed water immersion restraint stress was loade. Two hours after loading,fibrinolysis in blood and tissue increased further, and in accordance with it, bleeding and erosion were seen to a high degree in gastric mucosa. On the other hand, in the EACA group, in which anti-fibrinolytic agent, ε- amino carpic acid was administered, the increase was moderate in the fibrinolysis in blood and mucosa after loading the stress. Though bleeding and development of erosion were not completely controlled, values of fibriolytic activity of the tissue in the EACA group were lower than those of control group.

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