J.Jpn. Surg. Soc.. 86(3): 304-318, 1985

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Original article

EXPERIMENTAL STUDY ON INTRAHEPATIC GAS TENSIONS MEASURED BY MASS SPECTROMETRY：EFFECT OF TEMPORARY OCCLUSION OF THE AFFERENT HEPATIC CIRCULATION

In 24 mongrel dogs, a mass spectrometer was utilized to measure intrahepatic pO₂ and pCO₂ levels subjected to various degrees of inspired oxygen concentration, or interruption of the afferent hepatic circulation. The mean intrahepatic pO₂ and pCO₂ levels in dogs breathing 70％ O₂ were 46.0±13.3 (SD) mmHg and 27.4±13.0mmHg, respectively. Progressive rise of the intrahepatic pO₂ and pCO₂ was observed with increase in the arterial pO₂ and pCO₂ when the hepatic circulation was kept constant. When the hepatic artery was interrupted, mean intrahepatic pO₂ fell rapidly to 20％ of the control value, and mean intrahepatic pCO₂ rose to 200％. Rather wide dispersion of the values among the experimental animals during the hepatic artery interruption was speculated to reflect the variety of collateral hepatic arterial supply and various degrees of congestion of portal blood flow.
Transient decrease in the mean intrahepatic pO₂ was observed following interruption of the portal vein. Intrahepatic pO₂ rapidly fell to zero and pCO₂ increased in a lineal fashion when the total hepatic circulation was interrupted. The latter rose to 453％ of the control value 30 minutes after interruption, then the rate of rise gradually decreased until a plateau was reached one hour later. This decrease in the rate of rise in intrahepatic pCO₂ was regarded to reflect the reduction of energy production through the anerobic pathway due to irreversible hepatic parenchymal degeneration. It is suggested that the measurement of intrahepatic gas tensions under various conditions by a mass spectrometer technique is useful for evaluating changes of intrahepatic microcirculation and dynamic aspects of anerobic metabolism of the Iiver.

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