J.Jpn. Surg. Soc.. 85(10): 1359-1369, 1984
Original article
A CLINICOPATHOLOGICAL STUDY ON THE HEMATOGENOUS RECURRENCE OF COLO-RECTAL CANCER
ーWITH SPECIAL REFERENCE TO THE PREDICTION AND PREVENTION OF THE RECURRENCEー
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First Department of Surgery, Kobe University School of Medicine, Kobe, Japan Yoshiki Tabuchi, Shiro Nakae, Kizuku Imanishi, Takeshi Nakamura, Hiroshi Kawasaki, Tadashi Ohyama, Yoshio Murayama, Yasuhiko Takiguchi, Yoichi Saitoh |
Hematogenous recurrence was confirmed in 34 cases including 25 liver, 5 lung, 2 bone, one brain and one skin recurrence. Most of the cases (28 cases, 82.4%) revealed a single or multiple hematogenons recurrences without showiug additional other types of recurrence. Histological examination of cancer lesions indicated that patients with the findings consisting of moderate and/or high grade of vein invasion (v2-3), subserosal and extramural vein invasion with node metastasis showed high recurrent rate. One and two year survival rate of the patients treated with MF-MF' adjuvant chemotherapy was greater those the patients with F-F' chemotherapy or those without chemotherapy. However, 3-, 4- and 5- year survival rate did not show significant difference among 3 therapeutic groups. The analysis of survival curves also indicated no significant difference among 3 therapeutic groups.
These results may suggest that hematogenous recurrence is derived from pre- and/or intra-operative micrometastasis or transplantation of cancer cells, that patients with the above mentioned histological evidence must be clinically treated as a high risk group for recurrence and that MF-MF' adjuvant chemotherapy can be effective in lowering the recunence rate during the first one or two years after operation.
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