J.Jpn. Surg. Soc.. 85(10): 1288-1300, 1984
Original article
A CLINICOPATHOLOGICAL STUDY ON GASTRIC CARCINOMA TREATED WITH PREOPERATIVE ANTICANCER CHEMOTHERAPY
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First Department of Surgery, Niigata University School of Medicine, Niigata, Japan Atsushi Nashimoto |
1) Not only morphologic manifestations observed by X-ray and endoscopy, but also histopathologic findings of biopsied specimens taken after treatment with 5-FU for 12 consecutive days, were effectively used for judging the sensitivity of cancerous tissue to anticancer agents in vivo.
2) Effective rates were high in cases treated with oral administration of 5-FU more than 500mg/day and 5.0gr as a total dose (p＜0.01), and the incidence of anticancer-induced-gastritis was also seen high in cases with oral administration of 5-FU more than 500mg/day and 6.0gr as a total dose (p＜0.005). The proper dosage of 5-FU orally administered was, therefore, 500mg/day and 5.0gr. as a total dose.
3) Histologic effects of anticancer agents on primary lesions were in accordance with those of metastatic foci of lymph nodes (p＜0.01).
4) 5-FU when orally administered resulted in a low rate of significant toxity (23.5%), and no serious side-effects. In conclusion, it is considered that preoperative anticancer chemotherapy on gastric carcinoma apparently causes cancer cell death, decrease viability of cancer cells, makes it possible to detect in-vivo sensitivity for anticancer agents, and will improve the late survivals of patients with gastric carcmoma.
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