J.Jpn. Surg. Soc.. 85(9): 1166-1169, 1984

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Report on the annual meeting

THROMBOLYTIC AGENTS

The clinical efficacy of thrombolytic agents, urokinase, lysyl-plasminogen and batroxobin, was evaluated on the patients with deep venous thrombosis. In the group treated with combination of batroxobin, lysyl-plasminogen and urokinase, significantly better efficacy was obtained over the urokinase group in terms of judgement on venography and clinical improvement.
Plasma fibrinogen, plasminogen and α₂-plasmin inhibitor were markedly reduced by batroxobin infusion. Fibrinolytic activity measured by plasminogen-free fibrin plate method was detected in 89 % of blood samples taken after 120,000 I.U. urokinase infusion following lysylplasminogen administration.
These results suggested that even moderate dosage of urokinase could induce fibrinolytic activity under conditions of low α₂-plasmin inhibitor and fibrinogen levels caused by batroxobin and additional lysylplasminogen.

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