J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1956KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 85(9): 1143-1146, 1984

Report on the annual meeting

LOCAL ADMINISTRATION OF ANTI-CANCER DRUGS

1) Second Dpt of Surg, Fukui Med. Coll., Fukui, Japan
2) Dpt of Pharm, Kyoto University, Kyoto, Japan
3) Kohri Hosp, Kansai Med. Coll.,
4) 2nd Dpt of Surg, Kyoto University, Kyoto, Japan

Nobuhiko Tanigawa1), Mitsuru Hashida2), Hitoshi Sezaki2), Masahiro Fujii3), Tomokuni Shiraishi3), Yoko Harima, Akira Arimoto4), Kazuo Honda4), Tetsuji Hanafusa4), Keiichiro Mori4), Takashi Inamoto4), Nobuaki Kobayashi4), Koichi Tanaka4), Hiroshi Tanimura4), Kaoru Kumada4), Kisaku Satomura4), Yorinori Hikasa4)

Anti-cancer drugs in the forms of an emulsion, a microsphere, and of conjugates with high molecular dextran have been developed in our laboratories, namely a fat emulsion of anticancer drug, MMC-microsphere, or MMC-dextran conjugates. The main advantages of these forms of pharmaceutical preparation are that they give prolongation of pharmacological actions by slow release and that they are applicable for topical use because of their reduced toxicities to local tissue yet maintaining local therapeuatic potency. In this study we found that the rate of sustained release of drugs and antitumor effects were enhanced when used in such modified forms of drugs for topical injections. Results of clincal trials of those drugs have been promising.
However, the number of trials has been limited so far. Further studies would be required for evaluating on of their clinical utilities.

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