[
Abstract]
[
Full Text PDF] (in Japanese / 2359KB)
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J.Jpn. Surg. Soc.. 83(9): 1136-1140, 1982
Report on the annual meeting
MANAGEMENT OF MULTIPLE ORGAN FAILURE AFTER SURGERY OF DIGESTIVE ORGANS
-With Special Reference to Postoperative Acute Gastroduodenal Ulcers-
Acute gastroduodenal ulcers after surgery of digestive organs were studied in 84 patients with respect to clinical problems, particulary in relation to multiple organ failure. In adition, in an attempt to predict the development of acute ulcers and to assess the effectiveness of the treatment, 107 rats and 8 clinical cases were subjected to investigation.
The results obtaind were as follows:
1. Postoperative acute gastroduodenal ulcers were observed as a part of the multiple organ failure and showed very poor prognosis.
2. In the experimental model of the acute ulcers using restraint and water immersing stress rats gastric pH and transmucosal electric potential difference (PD) showed close relation to both ulcer index and energy metabolism in the gastric mucosa.
3. When PD was measured continuously in clinical cases with postoperative acute gastroduodenal ulcers, PD showed very low level at bleeding and tended to recover to normal level when bleeding ceased.
4. Since pH and PD seemed to be good parameters to predict the development of acute ulcer and to assess the effectiveness of the treatment, aggressive clinical application of the measurement of pH and PD is to be expected.
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