J.Jpn. Surg. Soc.. 83(9): 916-920, 1982

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Report on the annual meeting

AGGRESSIVE SURGICAL APPROACH TO STAGE III AND IV NEUROBLASTOMA PATIENTS

Thirty four neuroblastoma patients were reviewed. All patients of stage I, II, and IV^s survived, but one of 2 patients of stage III and four of 20 patients of stage IV have been alive without tumor more than two years since operations. Overall survival rate was 50 percent.
All primary tumors were removed in the patients of stage I, II, and IV^s except one who was not operated. All mediastinal stage IV patients had primary tumors removed, and four survived. On the other hand, primary tumors were removed in four of 14 patients of stage IV abdominal neuroblastoma, and all were dead. One stage III abdominal patient has been alive without tumor more than 9 YEARS SINCE REMOVAL OF PRIMARY TUMOR.
The possible reason of poor prognosis despite removal of primary tumor in stage IV abdominal neuroblastoma patients is widespread hematogenic and lymphatic metastases.
In conclusion, removal of primary tumor is not beneficial in stage IV abdominal neuroblastoma, but is beneficial in stage III abdominal and stage IV mediastinal neuroblastoma as well as stage I, II, and IV_s neuroblastoma.

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