J.Jpn. Surg. Soc.. 82(8): 907-917, 1981
Original article
GLUCOSE METABOLISM ON THE EXPERIMENTAL ACUTE PANCREATITIS
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First Department of Surgery, Okayama University School of Medicine (Director: Prof. Kunzo Orita) Toshinori Ohara |
The auto-bile pancreatitis group, the trypsin pancreatitis group, and the collagenase pancreatitis group were prepared, and changes of glucose, IRI, IRG and catecholamine were measured for 24 hours. In addition, 24 hous later IVGTT and on the seventh day the arginine loading test were conducted.
The rise of blood glucose was observed in the initial stage of acute pancreatitis, and this seems to be regulated by the balance of IRI and IRG, and the hypoglycemia in severe type of bile pancreatitis is interpreted to be due to a copious amount of insulin transudation following the destruction of Langerhans β cells, which subsequently flows into blood via the thoracic duct.
In IVGTT 24 hours later in all 3 groups IRI showed reaction as high as 3-5 times that of the normal, and IRG also showed a high reactivity. It seems there is a specific excessive reaction stage.
In the arginine loading test on the seventh day, both IRI and IRG showed a low reaction, indicating the functional decrease of the pancreatic endocrine.
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