J.Jpn. Surg. Soc.. 82(8): 823-840, 1981
Original article
A EXPERIMENTAL STUDY OF HYPERDYNAMIC CIRCULATION IN CANINE
SEPSIS -IN TERMS OF METABOLIC INFLUENCES-
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First Department of Surgery, Faculty of Medicine, University of Tokyo (Director: prof. Satoru Kusama, M.D.) Hidetaka Mochizuki, M.D. |
Peripheral glucose uptake was increased despite hypoglycemia and hypoinsulinemia. Its uptake was further increased by glucose administration and glucose was effectively oxidized, which suggested that there were no evidence of insulin resistance and disorder of glucose utilization. Energy defecit in sepsis was assumed to be compensated with amino acids which were derived from skeletal muscle break down. Myocardial function was suppressed when cardiac preload was increased by volume loading, but it was significantly improved by glucose administration. When glucose or glucose and amino acid were administered to septic dogs, not only the improvement of cardiac function and peripheral energic metabolism but also peripheral sparing effect of branched chain amino acids were obtained. It was also indicated that peripheral metabolic state got more favorable by the acceleration of hyperdynamic circulatory state following dopamine administration.
It is concluded that hyperdynamic circulation in sepsis is an advantageous reaction for septic subjects and that enough glucose administration is effective for maintenance of this hyperdynamic state and compensation for energy deficit in sepsis.
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