J.Jpn. Surg. Soc.. 82(8): 807-822, 1981
Original article
VARIOUS MODES OF TREATMENT WITH AN IMMUNOGLOBULIN PREPARATION FOR INTRAVENOUS INJECTION
-THE OPTJMEL DOSAGE SCHEDULE AND THE UPPER LIMITS OF THE NUMBER OF INJECTIONS AND THE INITIAL AND TOTAL DOSES-
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2nd Department of Surgery, Hokkaido University School of Medicine Hiroyoshi Matsukura, M.D. |
1) Effect to prevent postoperative complications by infections depends on initial doses of the immunoglobulin.
2) The immunoglobulin in combination with suitable antibiotics was considered to prevent the occurence of infections with pseudomonas aeruginosa.
3) Fever was relieved earlier, when immunoglobulin was given in an early stage within 2 days after onset of infectious complications in combination with suitable antibiotics and injected every day for 3 or more days. Total dose of immunoglobulin should be more than 150 mg/kg within 5 to 6 days.
4) About one third of patients were unresponsive to immunoglobulin treatment within 5 to 6 days. These cases had severe complications, prolonged fever and required immunoglobulin for a long time.
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