J.Jpn. Surg. Soc.. 82(4): 316-323, 1981

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Original article

STUDIES ON CHANGES OF SERUM ZINC AND ALBUMIN, AND COLLAGEN-HYDROXYPROLINE CONTENTS IN GUT DURING EXPERIMENTAL TOTAL PARENTERAL NUTRITION

Changes of serum zinc and albumin levels before and after two weeks of total parenteral nutrilion were studied in 36 mongrel dogs, of which 14 were nourished with supplementation of zinc and the remaining 22 were nourished without supplementation of zinc. Ten dogs nourished with commercially available dog foods were also subjected to the studies and served as control group. Collagen-hydroxyproline contents of injured as well as uninjured guts were studied one week after incision and suturing of the gut in those nourished by total parenteral nutrition. Collagen-hydroxyproline contents of the uninjured gut were also studied in dogs nourished by oral feeding and served as control group.
It was disclosed from the present studies that serum zinc level in dogs nourished by solution without supplementation of zinc fell rapidly within one week of total parenteral nutrition and this fall of serum zinc level was accompanied by corresponding fall of serum albumin, and that collagen-hydroxyproline contents of injured as well as uninjured guts were markedly decreased in dogs nourished without supplementation of zinc, when compared with dogs having supplementation of zinc, or nourished by oral feeding.

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