J.Jpn. Surg. Soc.. 82(3): 271-276, 1981

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Original article

HEPATITIS ASSOCIATED WITH TRANSFUSION FOLLOWING CARDIOVASCULAR SURGERY

A survey on hepatitis associated with transfusion after cardiovascular surgery was conducted on those of 302 patients who were operated at the National Cardiovascular Center dming two years periods from July, 1977 to June, 1979. The minimum follow up was three months. The criteria for hepatitis associated to transfusion was defined as the elevation of serum enzymes (SCOT and/or SGPT) over 200 units later than three weeks of postoperative period.
The overall incidence was 23.5%. No difference was found in age, sex, year and type of surgery. The latent period was one to three months following surgery in 70% of cases. A correlation between high elevation of serum enzymes and prolonged cure from hepatitis were observed, however, there was no close relationships between the degree of enzyme level and duration of illness. Two apparent observations were found. The amount of blood transfusion over 21 units as well as fresh frozen plasma over 6 units were significantly correlating to the incidence of hepatitis (P= 0.05 and P＜0.005, respectively). In majority of cases of hepatitis, HBs antigen were negative, which suggest that hepatitis associated with transfusion may be induced by non-A or non-B type viruses

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