J.Jpn. Surg. Soc.. 82(3): 262-270, 1981

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Original article

LIPOPEROXIDE IN REGENERATING RAT LIVER

After about 70% surgical removal of the rat liver, the residual liver was resected as planned in order to study changes of lipoperoxide in the liver parenchyma and blood during the period of regeneration. Furthermore studies were carried out on changes of superoxide dismutase (SOD), catalase, glutathion peroxidase (GSH-Px) and α-tocopherol (Vitamin E) that played the important role in the defence mechanism of lipid oxidation.
The results were as follows. Lipoperoxide in the regenerating liver started to increase after 6 postoperative hours and it rose to the highest level during 18 to 24 postoperative hours, which was about 7 times as high as the control value. Then it decreased gradually and it recovered to the level of the control 5 days later.
On the other hand, changes of blood lipoperoxide demonstrated the adverse pattern those of liver homogenate. Namely, it showed rapid drop immediately after the operation. However it increased gradually and was at the maximum level on the third postoperative day which ranged to about 70% of the control. On the seventh postoperative day, it remained at the low level of about 50% of the control.
The SOD activity of the regenerating liver continued about the same level of the control up to 10 days after the operation, showed no significant differences.
The catalase activity decreased to about 60% of the control value on the first postoperative day and it continued at the same level up to the tenth postoperative day.
The GSH-Px activity showed gradual increase after the operation and recovered to about the same level of the control 5 days later.
The changes of vitamin E on the first postoperative day, it was too low to be detectable. But it increased to about 10% of the control on the second and third postoperative days. Thereafter it increased in its value to about 60% of the control during 5 to 10 postoperative days.
From the results reported above, it was suggested that the liver in the initial stage of regeneration was in the state where lipid peroxide were readily produced. And that lipoperoxide had the inverse relation in parenchyma and in blood. It is the point that must be borne in mind in clinical practice.

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