J.Jpn. Surg. Soc.. 82(3): 252-261, 1981

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Original article

XPERIMENTAL STUDIES ON GASTRIC SECRETION AND SERUM GASTRIN LEVEL AFTER MASSIVE SMALL BOWEL RESECTION

The influences of the 75% proximal or distal small bowel resection on gastric secretion and serum gastrin level were studied in dogs with Heidenhain pouches. Concentrations of gastrin were measured in the sera obtained from the superior mesenteric vessels to study the degree of gastrin inactivation in the small bowel.
Gastric secretion to test meal was increased after 75% proximal small bowel resection, but decreased after 75% distal resection. Serum gastrin levels were increased in the peripheral vein after both proximal and distal bowel resection. Gastric secretion to AOC-tetragastrin was increased after 75% proximal small bowel resection. These results suggest an increased response of parietal cells to gastrin after massive proximal small bowel resection.
Serum gastrin levels to test meal was lower in the superior mesenteric vein than in the artery. This suggets that secreted gastrin is inactivated in the small bowel in some part.
From these observations, it is reasonable to assume that gastric hypersecretion after 75% proximal small bowel resection is resulted, at least in part, from 1) the rise of serum gastrin levels due to the decreased inactivation of the hormone and 2) the increased response of the parietal cells to gatrin after surgery.

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