J.Jpn. Surg. Soc.. 81(12): 1576-1584, 1980

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Original article

STUDIES ON THE RELATIONSHIP BETWEEN CHANGES IN PANCREATIC EXOCREINE SECRETION FUNCTION AND SERUM SECRETIN AND GASTRIN SECRETION IN GASTRECTOMIZED DOGS ACCORDING TO RECONSTRUCTION ROUTE

Mongrel dogs weighing 10 to 20 kg underwent pancreatic duct drainage and B-I, II gastrectomy. Controls were mongrel dogs that did not undergo gastrectomy. For a test meal, 300 g beef liver was given 5 days later and observations were performed for a period of 120 minutes. Pancreatic juice was collected at intervals of 15 minutes and changes in pancreatic secretions observed. In all groups peripheral blood samples were obtained every 15 minutes for measurement of IRS and IRG.
The results were as follows :
1) Gastrectomized dogs showed depressed exocrin pancreatic secretion before and after the test meal. Distinct differences between B-I and B-II groups were observed. For example, in the B-I group a gradual increase in pancreatic juice volume was recognized but no reaction to the test meal was observed in the B-II group.
2) Secretin responses following the test meal were not observed in either gastrectomy group but the IRG of B-I showed significant response due to extragastric gastrin.
3) Differences of exocrine pancreatic secretion between B-I and B-II after eating liver were caused by differences in release of CCK-PZ and other humoral agents apart from secretin.
4) In the control group, secretin was not so influential on the early enhancement of exocrine function after the stimulation, and it was presumed that the moderately presisting secretion of secretin was synergistic with other humoral factors, CCK-PZ and VIP etc.

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