J.Jpn. Surg. Soc.. 81(10): 1315-1331, 1980
Original article
INFLUENCE OF THE EXTERNAL BILIARY DIVERSION TO CANINE STEROIDGENIC RESPONSE IN THE ADRENAL GLAND AND OVARY
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Department of the Second Surgery, School of Medicine, Kanazawa University, Japan Yoshitaka Kuroda |
1) No alternative change of hepatic function nor serum electrolyte level was found subsequent 8 weeks after the diversion.
2) In 73 % of experimental animals, 47－52% decrease of the serum cortisol level stimulated by rapid ACTH test from 2 weeks after the external biliary fistula suggested that an adrenocortical insufficiency might be occured.
3) The adrenal lipids, in these 73% animals not only showed a marked depletion of free cholesterol, triglyceride and cholesteryl ester to about half content of the control, in residual 27% animals but also revealed an about 30% of reduction of free and esterified cholesterol. These findings suggested the chronic stimulation of ACTH to the adrenal gland and a significant influence to the cholesterol metabolism after the diversion.
4) Slight decline of oleic and arachidonic acid and significant increment of 22-carbon tetraenoic acid of adrenal cholesteryl esters suggested a predictable steroidgenic response of hydrolysis of the esterified cholesterol.
5) Marked depletion of free and esterified cholesterol content to 7－27% of control in ovary suggested an ovarial dysfunction with a block of estrogenous enterohepatic circulation.
It is concluded that a recognition of adrenocortical dysfunction must be required at the second surgery after the external bilialy diversion due to a marked obstructive jaundice and an availability of the external biliary diversion may be possible to the castration therapy of breast cancer.
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