J.Jpn. Surg. Soc.. 80(12): 1432-1436, 1979
Report on the annual meeting
SPECIFIC IMMUNOTHERAPY WITH IMMUNE-RNA IN CANCER PATIENTS AFTER SURGERY
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First Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan Matsuro Fukushima |
This study included a total of 98 selected cancer patients consisting of gastric, esophageal and lung cancer. The stage, grade and invasive characteristics of the malignancies in these patients was equal in degree of advancement at the onset of this study. Fourty-seven cases were initially treated with resection followed by a course of immunotherapy using I-RNA sensitized lymphocytes. The distribution of these cases included 28 gastric cancer, 11 esophageal cancer and 8 lung cancer. Statistics of the five-year survival rate of the 47 cases treated with both resection and I-RNA were 35% for gastric cancer, 29% for esophageal cancer and 25% for lung cancer.
The control group consisted of 51 cases with the following distribution; 34 cases of gastric cancer, 9 esophageal cancer and 8 lung cancer. These patients were all treated in resection alone. All of these patients had expired from tumor recurrence within 4 years.
Immunological responsiveness of these patients was observed before and after the immunotherapy. In 4 cases, MIT became positive after the immunotherapy and LAI became positive in one case.
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