J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1579KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 80(12): 1416-1419, 1979

Report on the annual meeting

IMMUNOLOGICAL ASSESSMENT OF REGIONAL LYMPH NODES AND PROPHYLACTIC LYMPH NODE DISSECTION

Department of Surgery, Institute of Medical Science Hospital, University of Tokyo, Tokyo

Genshichiro Fujii, Morimasa Sekiguchi, Yoshio Samaru, Yoju Miyamoto, Isao Osada, Tsuneatsu Mori, Shinsuke Mikamo, Masazumi Eriguch, Gen Murakami, Tetsuro Hagihara

This study sought to determine if activated immune cells affected metastatic spread of cancer and current prophylactic lymph node dissection was rational. Lymph node and organ metastasis of MH134 and MM-2 tumors of C3H/He strain in athymic BALB/c-nu/nu mice was accelerated when the mice were reared in specific pathogen free (SPF) conditions, but not in the conventional conditions that might stimulate immune cells other than T cells. In the syngeneic C3H/He mice, metastatic spread of MH134 tumor was significantly reduced by stimulating regional lymph nodes with various nonspecific immunostimulants before surgical removal of the original tumor. The metastasis, however, was not reduced when surgical removal of the original tumor was delayed.
Compared to these animal experiments, in human breast cancer, hyperplastic reactivity of regional lymph nodes against metastatic spread was not demonstrated except for patients in early stage with no lymph node metastasis.
From these results and also due to the high incidence of microscopic cancer involmement in clinical negative nodes, it was considerred that current prophylactic lymph node dissection should be carried out in the advanced cancer until new anti-cancer chemotherapy and/or immunotherapy would be able to control completely residual minimal tumor in the regional lymph nodes after surgery.

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