J.Jpn. Surg. Soc.. 80(12): 1390-1394, 1979
Report on the annual meeting
NECESSITY OF THE IMMUNOTHERAPY IN THE PRE-AND POST-OPERATIVE CANCER STATE
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First Department of Surgery, Okayama University Medical School Kunzo Orita |
1. In the advanced cancer patients received curative resection, the activities of cytotoxic T cell (Tc cell) and delayed hypersensitivity initiation T cell (TD cell) turn out negative in 4-8 weeks after operation. There activities are thought to be useful to inhibit the cancer growth. So in such curative cases, it is necessary to do postoperatively active immunotherapy using the extirpated autochthonous tumor tissues or cultured tumor cells with crossing antigens. It takes 2 years that PHA blastgenesis restores to lower limit of normal level in the curative cases without relapse. Therefore, the long term, nonspecific immunotherapy will be required to shorten these two years as early as possible.
2. In the advanced cancer patients received non-curative resection, TD activity turns out positive within 1 month after operation, but Tc activity does not restore. The blocking factor which inhibits Tc and TD activity decreases and disappears 4-6 weeks after operation. There is no tendency to restore in PHA blastgenesis. If the intensive administration of immunopotentiators will be carried out during disappearance of blocking factor, it will be expected that both non-specific and specific cellmediated immunity restore and increase.
3. As immunological level decrease for 1 month after operation by surgical operation itself, it is essential to add preoperative nonspecific immunotherapy in all cases.
4. The preoperative and postoperative administration of levamisole are thought to make up such dimerits and to accelerate such merits as described above.
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