J.Jpn. Surg. Soc.. 80(12): 1385-1389, 1979

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Report on the annual meeting

EXPERIMENTAL STUDIES ON OPERATIVE STRESS IN SURGERY FOR CANCER

To evaluate the influence of operative stress in cancer surgery, thoracotomy and/or laparotomy were performed 48 hrs after intraperitoneal or intravenous inoculation of Sato lung cancer cells in Donryu rats. In the intraperitoneal inoculation, the survival time was observed. In the intravenous inoculation, the survival time and the number of lung metastases were examined. Thoracotomy and laparothoracotomy reduced the survival time and increased the number of lung metastases significantly. From the view point of enhancing the tumor growth, it was suggested that the operative stress of one hour thoracotomy was equivalent to that of five hour laparotomy. From the investigations of timing of the operation, the operative stress enhanced the tumor growth most dramatically when it was loaded on day－1 or 0 from the inoculation of tumor cells. Furthermore, 4 ml bleeding in addition to laparothoracotomy indicated significant enhancement of tumor growth. These results suggest to us in respect of the clinical application of thoracotomy, that operative results should be improved by neutralizing the deterious effect of thoracotomy on host resistance.

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