J.Jpn. Surg. Soc.. 80(11): 1135-1138, 1979

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Report on the annual meeting

RECONSTRUCTIVE ARTERIAL SURGERY IN PERIPHERAL OBLITERATIVE ATHEROSCLEROSIS

Out of 132 patients with arteriosclerotic obliterans who had been treated in our surgical department, 83 patients was subjected to reconstructive arterial surgery. The incidence of associeted disease at the time of operation was high. In 35 patients subjected to open thromboendarterectomy, the postoperative mortality was 7/35, with 60% of reconstructions being open after an observation period of 5 years. In 38 patients undergoing arterial bypass or replacement procedure, the postoperative mortality was 6/38, and these patency was 70% after an observation period of 5 years.
In order to improve the patency rate after reconstructive arterial surgery on patiens suffering from obliterating femoral arteriosclerosis, defibrinogenation therapy was subjected. The patients who treated with Batroxobin after arterial reconstruction or concervatively, plasma fibrinogen concentration decreased 40 to 80 mg/dl. But other coagulation facters were not changed markedly after defibrinogenation therapy. No bleeding and thrombo-embolic complication were observed in all patients.
The ankle/arm pressure index had increased by low lebel fibrinogen during treatment with Batoroxobin. Defibrinogenation therapy may be a useful theraputic maneuver in the treatment of thrombus formation and ciculatory insufficiency.

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