J.Jpn. Surg. Soc.. 80(6): 572-588, 1979
Original article
EFFECTS OF INTRAVENOUS HYPERALIMENTATION ON THE LIVER WITH OBSTRUCTIVE JAUNDICE
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The First Department of Surgery, St. Marianna University, School of Medicine (Director : Prof. Hiromu Watanabe) Kazuo Kanasugi |
Serum total bilirubin, direct bilirubin, transaminases, alkaline phosphatase, total cholesterol and triglyceride were elevated following ligation of bile duct, however no remarkable changes occured in these during I.V.H. Blood glucose control mechanism was maintained under hypertonic glucose or fructose loading (12 g/kg/day) in the bile-duct-ligated mongrels (total bilirubin under 10 mg/dl).
Low glycogen concentration in the liver suggested glycogenolysis except slight decrease in the group fed by I.V.H. with fructose. Glucose, G-6-P, F-6-P, Lactate and Pyruvate levels of the liver were elevated in the groups fed by I.V.H., but decreased in the group fed by dog food (CD-1). High Lactate/ Pyruvate ratio in the I.V.H. groups suggested activation of gluconeogenesis.
There was no evidence of cell infiltration, increasing of fibrosis, change of Glisson's capsule and proliferation of bile canaliculi in each groups.
The pyknosis and karyorrhexis of nuclei of hepatic parenchymal cells were prominent in the dog food group, but slight in the I.V.H. groups. Fatty droplets of cytoplasms of hepatic cells and P.A.S. positive substance were prominent in the I.V.H. groups with obstructive jaundice, but derangement and focal necrosis of the parenchymal cells were not so prominently observed. It showed a response to intravenous hyperalimentation under obstructive jaundice that the Kupffer's cells were more mobilized in the bile-duct-ligated I.V.H. groups.
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