J.Jpn. Surg. Soc.. 80(6): 542-551, 1979

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Original article

STUDIES ON CARBOHYDRATE METABOLISM AND HORMONAL CHANGES AFTER MAJOR RESECTION OF THE PANCERS,WITH SPECIAL REFERENCE TO SO-CALLED SANDMEYER'S DIABETES

Changes in glucose tolerance after the major resection of the canine pancreas can be correlated to the extent of pancreatectomy. Immediately after the removal of more than 88 per-cent of the pancreatic tissue, hyperglycemia developed (Type I). When 70 to 88 per-cent was resected, so-called Sandmeyer's diabetes occurred 10 or more weeks postoperatively (Type II). No diabetes was induced by less than 70 per-cent pancreatectomy. In Type I, insulin tolerance test, revealed decreased insulin sensitivity and assimilation index. Recovery of blood sugar from the lowest level after insulin load delayed, with degeneration or disappearance of the islet cells, both A and B, showing onset of diabetes in early postoperative periods. In Type II, in Sandmeyer's diabetes insulin sensitivity and assimilation index occured much later but prompt rise of the blood sugar from the lowest level, accompanying degeneration of B cells, but that of A cells was not observed. These results anti-insulin system is actively functioning, but insulin secretion seems to be exhausted. Hyperplasia of the islet cells were not found in all types.

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