J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2769KB） [Members Only And Two Factor Auth.][Back to Search Results]

J.Jpn. Surg. Soc.. 80(4): 299-306, 1979

Original article

STUDIES ON TUMOR-SPECIFIC CELL-MEDIATED IMMUNITY IN CANCER PATIENTS USING A MIXED LYMPHOCYTE-TUMOR CELL CULTURE REACTION
PART II. CORRELATION BETWEEN MLTR AND NON-SPECIFIC IMMUNOLOGICAL REACTIVITY AND PROGNOSIS

Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, Hiroshima (Director : Prof. T. Hattori)

Hiroshi IKEDA

Fifty-six cancer patients were studied on their tumor specific immunological reactivity using a mixed lymphocyte-tumor cell culture reaction (MLTR). In this paper, correlation between MLTR and non specific immunological reactivity and prognosis was reported. The following results were obtained :
1) Positive blasstogenic responses in MLTR were observed in 15 of 56 cancer patients.
2) MLTR was well related to DNCB skin test (P＜0.001), but not to PPD or PHA skin tests.
3) Peripheral lymphocyte count was not significantly related to MLTR. However, lymphocyte count was more than 2,000/mm3 in 10 of 12 positive cases for MLTR.
4) Serum immunoglobulin level was not related to MLTR .
5) In gastric cancer patients, positive blastogenic responses were observed in 1 of 8, 4 of 11 and 3 of 20 patients, in stage I+ II, stage III and stage IV, respectively.
6) In non-curative cases, a significant correlation was indicated between MLTR and prognosis (r=0.782, P＜0.001).
Finally, it was suggested that the intensity of tumor specific immune response was related to general immunocompetence and prognosis.

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