[
Abstract]
[
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J.Jpn. Surg. Soc.. 79(9): 996-1001, 1978
Report on the annual meeting
TREATMENT FOR ADVANCED SOLID TUMORS IN INFANCY AND CHILDHOOD WITH SPECIAL REFERENCE TO NEUROBLASTOMA, NEPHROBLASTOMA AND ENDODERMAL SINUS TUMOR
Our experiences in treating advanced solid tumors including neuroblastoma, nephroblastoma, endodermal sinus tumor and gonadal stromal tumor were reviewed. By our definition, there were 89 "advanced" cases in 114 patients having these tumors, and only 14 of the 89 patients survived.
Among the 14 survivors, there were six infants with neuroblastoma treated at the age of one year or younger. The following survivors are particularly noteworthy, because they apparantly belong to the truly high risk group.
Case 1. 6 year old boy. Stage III neuroblastoma with highly undifferentiated histology.
Case 2. 19 month old boy. Wilms' tumor with hematogenous hepatic metastases.
Case 3. 5 month old boy. Gonadal stromal tumor with extensive retroperitoneal metastasis.
Case 4. 4 year old girl. Sacrococcygeal endodermal sinus tumor treated with radical excision and intensive chemotherapy.
It seems that the minimum requirements for survival of these advanced cases are radical surgery, intensive chemotherapy and radiotherapy covering the whole tumor bed . Any failure in conducting these therapeutic modalities will lead to death of the patient.
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