J.Jpn. Surg. Soc.. 79(9): 955-960, 1978

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Report on the annual meeting

A SCREENING MODEL FOR THE CHILDHOOD SOLID TUMORS: THERAPEUTIC CONSIDERATIONS OF C1300 MURINE NEUROBLASTOMA SYSTEM

This study was undertaken to study surgical adjuvants in the therapy of childhood neuroblastoma. The system we have chosen is the C1300 murine neuroblastoma (MNB) system : this line resembles in many respects the human neuroblastoma. This system is effective in the analysis of kinetic, radiologic and chemotherapeutic parameters of neuroblastoma management.
The results on chemotherapy or radiation therapy suggest that the murine neuroblastoma preparation may be useful as a screening technique for human neuroblastoma therapy and should assist in the design of new surgical adjuvants for this disease although the mouse tumor is not entirely the same as the human tumors especially in immunological aspects.
Another objective of this study is to clarify the effects of preoperative and intraoperative cancer drugs administration on patients with malignant tumors. A/J mice were inoculated with tissue-cultured and ⁵¹Cr-labeled MNB cells intravenously. The mice were sacrificed after injection periodically and radioactive distributions in each organs were measured . The group which was pretreated with cyclophosphamide had extremely lower level of ⁵¹Cr-radioactivity. The result suggests that adequate preoperative or intraoperative chemotherapy may be effective to prevent the metastases and dissemination of the separated tumor cells into the other organs or tissues during the exicision of the tumor.
A follow-up study of the patients with Wilms’ tumor also suggests the same effect.

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