J.Jpn. Surg. Soc.. 78(1): 51-67, 1977

---

Original article

EFFECT OF SELECTIVE PROXYMAL VAGOTOMY ON GASTRIC PHASE OF ACID SECRETION IN DUODENAL ULCER PATIENTS

In this study a test to measure gastric phase of acid secretion was described and effect of selective proxymal vagotomy (SPV) on acid secretion in response to a test meal was evaluated using this test. After a basic study in 78 patients with gastro-duodenal diseases and 10 normal subjects, following studies were performed. (1) In 12 duodenal ulcer patients (DU) meat-stimulated gastrin release and acid secretion were determined using this test and compared with the results in insulin test. (2) Eight DU patients were examined before SPV and the second week, third month, sixth month and twelfth month in the postoperative period repeatedly, and acid reduction rate in each period was calculated. (3) The responses in the test in 18 patients after SPV were determined and compared with those in 5 patients after selective gastric vagotomy (SV) .
As conclusions, these studies suggested, (1) increased rate of gastric phase of acid secretion in preoperative DU may be caused chiefly by an increased responsiveness of functional oxyntic cell mass in DU, (2) gastric phase of acid secretion was reduced by 70.4% 3 months and 46.6% 12 months after SPV through a decreased acid-secreting ability and responsiveness of functional oxyntic cell mass, and (3) the postulated concept that vagal denervation of the antrum reduces gastrin release and acid secretion in response to a test meal can be supported partly by a comparison of the results in the patients after SPV and SV.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.