J.Jpn. Surg. Soc.. 78(1): 25-36, 1977

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Original article

STUDIES ON PROGNOSIS AND SURGICAL INDICATION OF BILIARY ATRESIA BY HISTOLOGICAL FINDINGS

Liver specimens from 68 cases of biliary atresia were histologically studied in reference to postoperative prognosis, and an attempt to determine the surgical indication from histological findings was made with this study. For this purpose, following two studies were carried out on these specimens. 1) To investigate the relation between histology of the liver and postoperative bile excretion, the degree of some elementary histological changes were compared with patient's age at operation and postoperative bile flow. 2) Histometrical findings with "multipurpose test system" were compared with postoperative bile flow.
From this study, it was shown that 1) marked fibrosis (cirrhosis) and interstitial areas occupying more than 35 % of the liver specimen, 2) severe ductular proliferation, shown by proliferated bile ducts occupying more than 20 % of interstitial areas, 3) no or slight intralobular cholestasis and 4) marked interlobular cholestasis are considered to predict poor postoperative bile excretion.

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