J.Jpn. Surg. Soc.. 62(10): 1076-1090, 1961
EXPERIMENTAL STUDIES ON THE EFFECT OF NORMOVOLEMIC BLOOD TRANSFUSION ON KIDNEY FUNCTION IN HEMORRHAGIC SHOCK
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Surgical Department, Keio-Gijuku University School of Medicine (Director: Prof. Nobukatsu SHIMADA) Osahiko ABE |
1. From the observation of the whole course of sustained hypotension of 50 mmHg due to bleeding, the stage of decompensation of circulatory system and the irreversible stage of hemorrhagic shock were ascertained.
2. The kidney function after normovolemic blood transfusion in either stadium demonstrated remarkable differences from each other regarding degree of disturbances and recovery from damage.
3. When the blood transfusion was performed in the former stage renal plasma flow and glomerular filtration rate revealed less decrease followed by more rapid restoration to normal values, whereas when transfusion was carried out in the latter stage they decreased severely with little or no restoration.
4. Accordingly the observation of kidney function is a good indicator of the effect of normovolemic blood transfusion on sustained hypotension due to hemorrhage.
5. The kidney function after normovolemic blood transfusion to dogs in which blocking of autonomic nervous system was performed prior to bleeding showed correlation with the deviated response before reinfusion.
6. Among the blocking of autonomic nervous system administration of chlorpromazine, exerted effect of prolonging reversible stage of hemorrhagic shock with resultant prolongation of the period during which development of irreversible shock could be prevented with kidney function restored.
(Author's abstract)
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