J.Jpn. Surg. Soc.. 60(11): 1832-1845, 1960

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THE ACTION OF MUSCLE RELAXANTS ON THE CENTRAL NERVOUS SYSTEM

E.E.G. was studied on the actions of muscle relaxants in two groups; in the former S.C.C. was given to cérébri isolé dog, in the latter, tubocuraine and S.C.C. were administered to the cérébri isolé spccimen after inducing convulsion waves by INAH and Cardiazol with the sufficient amount of oxygen.
1) Tubocurarine inhibits convulsion waves which is induced by convulsants.
2) In the resulted intermittent period, the single spike seizure waves remain, and these waves change to convulsion waves when the intermittent period is shortened.
3) When tubocurarine or S.C.C. is given with Cardiazol at the dose which does not produce the recurrent convulsions, these two agents induce the recurrent seizures.
4) When S.C.C. is given the spike and convulsion waves with spikes appear in EEG, which are similar to the intermittent period of convulsion waves.
5) S.C.C. may induce convulsion waves when it is given to cérébri isolé specimen.
6) It is confirmed from the above mentioned results that tubocurarine and S.C.C.act directly to the central nervous system, inhibit abnormal convultion waves temporarily and induce recurrent convulsion waves.
(Author's abstract)

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