J.Jpn. Surg. Soc.. 60(3): 394-426, 1959
BACTERIOLOGICAL STUDIES ON THE LIVER OF PATIENTS WITH VARIOUS ABDOMINAL DISEASE, WITH SPECIAL REFERENCE TO PORTAL HYPERTENSION
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2nd Department of Surgery, Nagoya University School of Medicine (Director: Prof. Hajime IMANAGA) Yoshinori NARITA |
The results obtained were as follows.
1. Aerobic and anaerobic cultures of the liver tissues from 10 patients without infection, ulcer, or cancer in gastrointestinal tract and bile tract were all negative. It could be concluded that normal human liver tissues were free from bacterial contamination.
2. Cultures of the liver tissues from 22 of 47 patients with portal hypertension (cirrhosis of the liver, Banti's syndrom and hepatic vein obstruction) were positive. Of 19 patients with cirrhosis of the liver 9 were positive and 10 strains of bacteria were isolated (Staph. aureus 4, Staph. albus 4, Micrococcus 1, Diphtheroid 1). Of 26 patients with Banti's syndrom 12 were positive and 15 strains were isolated (Staph. aureus 3, Staph. albus et citreus 3, Micrococcus 1, E. coli 1, Neisseria 1, Anaerobic micrococcus 6). Of 2 patients with hepatic vein obstruction 1 was positive and Staph. citreus was isolated.
Anaerobic micrococci were isolated mainly from the liver tissues suffering from not so obvious pathological changes of a secondary cirrhosis, while Staph. aureus were isolated mainly the liver tissues of moderate or severe cirrhosis.
Biles in the gall bladders from 6 patients with portal hypertension were all negative.
In 3 cases of portal hypertension cultures of the liver tissues were repeated more than two times at various intervals and the same species of bacteria could be isolated. The longest interval was 70 days and the bacterias isolated were resistant to some antibiotics used after the operations.
3. Of 5 patients with hepatoma 4 were positive and 4 strains were isolated (Staph. aureus 2, Staph. albus 2).
4. Of 32 patients with cancer of the stomach 13 were positive and 15 strains were isolated (Staph. albuset citreus 7, L. bifidus 3, Anaerobic streptococcus 2, Staph. aueus 1, Micrococcus 1, E. coli 1).
5. Of 12 patients with stomach or duodenal ulcer 5 were positive and 5 strains were isolated (Staph. albus 3, E. coli 1, Anaerobic micrococcus 1).
6. Of 19 patients with cholelithiasis of cancer of the gall bladder 15 were positive and 15 strains were isolated (Staph. albus 10, E. coli 3, Micrococcus 1, Clostridium 1). Herein, of 16 patients with cholelithiasis 14 were positive and its rate of the positive bacterial cultures was most high in the present investigation.
From biles in the gall bladders from 6 patients with cholelithiasis the same species of bacteria could be isolated as from the liver tissues.
7. Staphylococci were most numerously isolated from the liver tissues in the present investigation. Of 44 strains of the species almost a half were resistant to penicillin, 25 per cent were resistant to chloramphenicol and only 4.5 per cent were resistant to erythromycin.
(The author's abstract)
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