J.Jpn. Surg. Soc.. 59(13): 1990-2008, 1959

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EXPERIMENTAL STUDY OF CEREBRAL CIRCULATORY DISTURBBANCES ON THE HIGH ILEUS AND AFTER ITS RELIEF

For the purpose of ascertaining the effect of experimental high ileus and its reIief in dogs under anesthesia on the circulatory condition of the central nervous system, the morphological changes and the circulating blood volume of the brain have been investigated. The results obtained may be summarized as follows:
1. In cases of high ileus marked circulatory disturbances and scrious degenerative changes of the nerve cells develop and become intensified daily.
2. When high ileus is relieved on the second day of the experiment, the circulatory disturbances and nerve cell changes do not show any immediate recovery but rather exhibit temporary aggravation. A slight improvement begins to take place on the fourth day and on the 15th day almost normal picture is seen.
3. There are some instances in which the circulation shows a marked increase, though temporarily, seven days after the relief of high ileus.
4. Under deep anesthesia induced by the administration of various narcotics, a marked improvement in circulatory disturbance was recognized with barbiturate, ether and autonomic nerve blocking agents, while morphine hydrochloride even aggravated the condition without any effect on improvement.
(author's abstract)

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