J.Jpn. Surg. Soc.. 59(9): 1493-1512, 1958

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STUDIES ON ARTIFICIAL HEART-LUNG WITH APPLICATION OF HYPOTHERMIA, WITH SPECIAL REGARD TO THE HEART-LUNG APPARATUS AS THE OXYGENATOR OF WHICH AN IRRIGATOR WAS ADOPTED.

When hypothermia was applied, the occlusion time were able to be fully lengthened even with a low rate of the flow of the extracorporeal circulation.
In animal experiments the flow rate of the extracorpororeal circulation was 31 cc/kg/min in the normothermia group and as low as 26 cc/kg/min in the hypothermia group. Furthermore, while the former group survived 16 minute occlusion, the latter was able to survive 20 minute occlusion.
In a clinical case the average flow rate was 15.1 cc/kg/min when the general hypothermia including the head was applied (the rectum temperature : 32° C). With such a small rate, oxygenation was achieved satisfactorily because blood passed the oxygenator slowly.
Clinical application was made on 37 cases by January, 1957. Eight cases of them died, the death rate ammounting 21.6 per cent. Moreover, death which should be ascribed to the artificial heart-lung apparatus was observed in only 2 cases.
The oxygenator used by the present author is unique and quite simple. Blood is sprayed from the upper part of the irrigator and oxygen is bubbled from th bottom. Blood drops forming film around O₂-bubbles and being oxygenated.
The thicker the layer of the O₂-bubbles, the greater is the oxygenating capacity.
(author's abstract)

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