J.Jpn. Surg. Soc.. 59(3): 353-367, 1958

---

INFLUENCES OF THE HIBERNATION THERAPY AND ADRENO-CORTICAL HORMONE ON THE MORPHOLOGICAL CHANGES OF THE DUCTLESS GLANDS AT THE EARLY SHOCK STAGE OF HEAD INJURY (ANIMAL EXPERIMENT)

The shock condition could be observed by a head blow in rat. Immediately after initiation of the shock condition pharmacological hibernation and adreno-cortical hormone were applied by various combinations. Among many ductless glands the anterior lobe of the pituitary gland, thyroid gland and adrenal cortex were studied histologically.
Morphological changes of the following 6 groups were comparatively studied. (A) Head blow group. (B) Head blow+ Hibernation group. (C) Head blow+ Cortisone group. (D) Head blow+ Cortisone+ Hibernation group. (E) Head blow+ ACTH group. (F) Head blow+ ACTH+ Hibernation group.
1. In the group (A) cellular swelling, irregularity of the cellular arrangement, capillary hemorrhage and decrease of the chromatophilia were remarkable.
2. In the group (B) the changes which were observed in the group (A), were slight and they were similar to those of the non-traumatic cases.
3. Changes in the groups (C) and (E) were quite similar. Histological changes of the anterior lobe of the pituitary gland and the adrenal cortex were slighter in these groups than in the group (A) and they rather similar to the gruop (B). Changes of the thyroid gland in these groups were mostly similar to those of the group (A) . Accordingly, the adreno-cortical hormone is effective against the pituitary gland and adrenal gland, but it has mostly no effect on the thyroid gland.
4. Histological changes of the groups (D) and (F) were almost equal and there were least changes in these groups. Changes in the anterior lobe of the pituitary gland and adrenal cortex were similar to the changes of the nontraumatic cases. However, cellular proliferption was observed in these groups. Changes of the thyroid gland were mostly similar to the changes of the group (B).
According to the results mentioned above, when the hibernation therapy and adrenocortical hormone are applied at the early shock stage, morphological changes of the ductless glands are most similar to those of the nontraumatic cases. However, the adrenocrtical hormone is effective against the pituitary and adrenal glands, but it has almost no effect on the thyroid.
(author's abstract)

---

---

To read the PDF file you will need Adobe Reader installed on your computer.