J.Jpn. Surg. Soc.. 58(3): 365-375, 1957

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STUDIES ON THE CONTROL OF HIGHER AND PERIPHERAL AUTONOMIC SYSTEMS OVER THE ACTION OF CHOLINE AND CHOLINESTERASE.
PART I. A STUDY OF THE INFLUENCE OF PREFRONTAL SUBCORTICOTOMY SO-CALLED “T-TOMY” (TAKEBAYASHI) UPON THE ACTION OF SERUM CHOLINE AND CHOLINESTERASE

In numerous cases of autonomic unbalance, i. e., dyskinesis, Raynaud or Buerger's disease, Graves' disease, stomach ulcer etc., the actions of serum choline and choline- sterasew rere measured before and afteroperation, to with, T-tomy, Lobotomy, sympathectomy, stomach resection, strumectomy etc. Hereby biological method of magnus was used
1) After T-tomy increase of serum cholinesterase (s-ch E) and after Lobotomy decrease of s-ch E are noticed, specially apparent one week after operation and it continues some weeks or over a month.
2) Certain decrease of s-ch E is mostly observed in cases of sympathicotonia. Some increase of s-ch E is noticeable mostly in cases of parasympathectomy, resp. sympathectomized patients.
3) The phenomenon of defiinite increase of s-ch E is usually seen after T-tomy as well as after sympathectomy. The patient suffering from corticosymathicotonia should therefore be released by T-tomy.
4) Estimation of s-ch E is of clinical importance as to the diagnosis, prognosis of the disease or operative indication of autonomic disorders either of central or peripheral nature.
(author's abstract)

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