J.Jpn. Surg. Soc.. 57(12): 1981-1987, 1957

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EXPERIMENTAL STUDIES OF THE HYPERTONIC GLUCOSE SOLUTION INJECTION INTO THE CAROTID ARTERY UPON GASTRIC MOTILITY
Part 2. THE MECHANISM OF THE INHIBITION OF GASTRIC MOTILITY FOLLOWING HYPERTONIC GLUCOSE SOLUTION INJECTION INTO THE CAROTID ARTERY

In the 1st report I concluded that the carotid artery injection of hypertonic glucose solution resulted in an inhibition of gastric motility. So now in order to study the mechanism of the inhibition, I cut or destroyed the various parts of the rabbit's brain and obserbed the changes on the gastrograph following constant hypertonic glucose solution injection into the carotid artery. Results are as follows.
1. In rabbits subjected to the transection of the brain stem caudal from the diencephalon, there resulted no change or only slight acceleration in gastric motility
2. In diencephalon rabbits, injection resulted in a remarkable inhibition.
3. In rabbits subjected to the electrical coagulation of b-sympathetic zone (Kurotsu), the injection resulted in a slight acceleration and regularisation of the gastric motility.
4. In rabbits subjected to the electrical coagulation of c-parasympathetic zone or other parts of the diencephalon, the injection resulted in a remarkable inhibition.
From such results, mentioned above, it has been concluded that the inhibition of gastric motility by carotid artery injection of hypertonic glucose solution is caused by excitation of the hypothalamic b-sympathetic zone.
(author's abstract)

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