J.Jpn. Surg. Soc.. 56(12): 1607-1629, 1956
A STUDY OF POTENTIAL DIFFERENCE ACROSS THE STOMACH WALL
PART 1. EFFECT OF HYDROCHLORIC ACID
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2nd Surgical Clinic, Faculty of Medicine, Kyushu University (Director: Prof. M. Tomoda). Tetsuo KATO |
1. As measured in 74 cases, the P.D. across the stomach wall averaged 46 mv. on the fundic gland area and 34 mv. on the pyloric-greater on the former area than on the latter. The mucosa was invariably negative in the external circuit to the serosa.
2. The P.D. on the pyloric gland area was far more reduced by HCI in physiological concentrations and required a longer tim to return to the original Ievel than that on the fundic gland area.
3. The P.D. on the pyloric gland area was far more reduced by sulphuric acid in a definite concentration and took a Ionger time to return to the original level than that on the fundic area, substance acting in the same way as HCl in this respect.
4. The change produced by HCl in the P.D. appeared to depend a great deal on a change in the function of the superficial epithelium, and in its metabolic activity.
5. The P.D. on the fundic gland area was much more decreased by an alkali and took a longer time to return to the original level than that on the pyloric gland area.
The measurment thus showed that the mucosa of the pyloric area is more sensitive to HCI than that of the fundic.
(author's abstract)
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