J.Jpn. Surg. Soc.. 56(10): 1321-1338, 1956

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STUDIES ON THE CARBOHYDRATE METABOLISM IN ANESTHESIA
Part 1: CARBOHYDRATE METABOLISM DURING PENTOTHAL ENDOTRACHEAL ETHER ANESTHESIA AND ACUTE HYPOXIA

The author investigated the effect of pentothal, endotracheal ether anesthesia and acute hypoxia on the carbohydrate metabolism by hepatic cathetreization: and obtained the following results:
(1) Pentothal anesthesia decreased the splanchnic oxygen consumption, but provided it caused no hypoxia, its effect on the hepatic carbohydrate metabolism was insignificant.
(2) Endotracheal ether anesthesia decreased also the planchnic oxygen consumption. The hepatic glucose output and the blood lactic acid increased and the lactic-pyruvic acid ratio (L/P) rose as a result of slight decrease of blood pyruvic acid. However, the function that the liver disposed the blood lactic acid was weII preserved.
In an immediate post-anesthetic stadium a significant disturbance of carbohydrate metabolism was proved during O₂ insufflation.
(3) In acute hypoxia it was observed that the hepatic glucose output increased and the hepatic disposal function of lactic acid was lost.
(author's abstract)

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